PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene. Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine-Proline motifs. The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function. Studies have shown that the deregulation of Pin1 may play a pivotal role in various diseases. Notably, the up-regulation of Pin1 is implicated in certain cancers, and the down-regulation of Pin1 is implicated in Alzheimer's disease. Inhibitors of Pin1 may have therapeutic implications for cancer and immune disorders.
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Beta hairpin1,2-dimethoxyethaanCDC25CCDC27CSNK2A2Casein kinase 2Casein kinase 2, alpha 1DAB2FOXO4HIPK2IndirubinList of human protein-coding genes 3MPHOSPH1MYT1Mothers against decapentaplegic homolog 21,2-dimethoxyethaanPIN1 (gene)PLK1Parvulin 14Pin1Proline isomerization in epigeneticsRELASMAD (protein)SUPT5HSUV39H1StrigolactoneTretinoinWW domainWee1-like protein kinase
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PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene. Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine-Proline motifs. The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function. Studies have shown that the deregulation of Pin1 may play a pivotal role in various diseases. Notably, the up-regulation of Pin1 is implicated in certain cancers, and the down-regulation of Pin1 is implicated in Alzheimer's disease. Inhibitors of Pin1 may have therapeutic implications for cancer and immune disorders.
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Peptidyl-prolyl cis-trans isom ...... r cancer and immune disorders.
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Peptidyl-prolyl cis-trans isom ...... r cancer and immune disorders.
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PIN1
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