Paddy "Hands" O'Brien (1925 – 26 March 2016) was an Irish Gaelic footballer who played as a full-back at senior level for the Meath county team. Born in Skryne, County Meath, O'Brien was introduced to Gaelic football at Skryne National School under the tutelage of schoolmaster Brian Smyth. Gaelic football competitions were curtailed during the Emergency, however, he made his senior début with the Skryne club in 1942. A two-time championship medal winner with Skryne, O'Brien also enjoyed championship success with in Dublin.