Pennsylvania Route 997 (PA 997) is a 49.0-mile (78.9 km) route in Franklin and Cumberland counties in central Pennsylvania. The route runs from the Maryland state line south of Waynesboro, where it continues into that state as Maryland Route 64 (MD 64), north to PA 233 in the Upper Mifflin Township community of . PA 997 heads north from the state line through agricultural areas in the Cumberland Valley and passes through Waynesboro, where it intersects PA 16, and Mont Alto, where it intersects the south end of PA 233, before coming to U.S. Route 30 (US 30) in Greenwood. From here, the route turns northwest and comes to a junction with Interstate 81 (I-81) and PA 696 near Scotland and US 11 in Green Village. PA 997 crosses PA 433 in and heads north along the eastern border of Letterkenny A