Purine nucleotide cycle

The purine nucleotide cycle is a metabolic pathway in which ammonia and fumarate are generated from aspartate and inosine monophosphate (IMP) in order to regulate the levels of adenine nucleotides, as well as to facilitate the liberation of ammonia from amino acids. This pathway was first described by John Lowenstein, who outlined its importance in processes including amino acid catabolism and regulation of flux through glycolysis and the Krebs cycle.

Purine nucleotide cycle

The purine nucleotide cycle is a metabolic pathway in which ammonia and fumarate are generated from aspartate and inosine monophosphate (IMP) in order to regulate the levels of adenine nucleotides, as well as to facilitate the liberation of ammonia from amino acids. This pathway was first described by John Lowenstein, who outlined its importance in processes including amino acid catabolism and regulation of flux through glycolysis and the Krebs cycle.