R13 (drug)
R13 is a small-molecule flavonoid and orally active, potent, and selective agonist of the tropomyosin receptor kinase B (TrkB) – the main signaling receptor for the neurotrophin brain-derived neurotrophic factor (BDNF) – which is under development for the potential treatment of Alzheimer's disease. It is a structural modification and prodrug of 7,8-dihydroxyflavone (7,8-DHF, tropoflavin) with improved potency and pharmacokinetics, namely oral bioavailability and duration. The compound is a replacement for the earlier 7,8-DHF prodrug R7 and has similar properties to it. It was developed because while R7 displayed a good drug profile in animal studies, it showed almost no conversion into 7,8-DHF in human liver microsomes. In contrast to R7, R13 is readily hydrolyzed into 7,8-DHF in human liv
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R13 (drug)
R13 is a small-molecule flavonoid and orally active, potent, and selective agonist of the tropomyosin receptor kinase B (TrkB) – the main signaling receptor for the neurotrophin brain-derived neurotrophic factor (BDNF) – which is under development for the potential treatment of Alzheimer's disease. It is a structural modification and prodrug of 7,8-dihydroxyflavone (7,8-DHF, tropoflavin) with improved potency and pharmacokinetics, namely oral bioavailability and duration. The compound is a replacement for the earlier 7,8-DHF prodrug R7 and has similar properties to it. It was developed because while R7 displayed a good drug profile in animal studies, it showed almost no conversion into 7,8-DHF in human liver microsomes. In contrast to R7, R13 is readily hydrolyzed into 7,8-DHF in human liv
has abstract
R13 is a small-molecule flavon ...... DHF in human liver microsomes.
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CAS number
1609067-49-3
PubChem
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57,756,777
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1,012,330,551
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CAS number
drug name
R13
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IUPAC name
[8--4-oxo-2-phenylchromen-7-yl] N-methylcarbamate
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metabolites
PubChem
90,117,609
routes of administration
SMILES
CNCOC1=COCNC
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StdInChIKey
NWWRHMSYZTWUBD-UHFFFAOYSA-N
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subject
comment
R13 is a small-molecule flavon ...... yzed into 7,8-DHF in human liv
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label
R13 (drug)
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wasDerivedFrom
isPrimaryTopicOf
name
R13
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