Rancho Potrero de San Francisco or Rancho Potrero Nuevo was approximately 1,000-acre (4.0 km2) Mexican land grant in the present day Potrero Hill neighborhood of San Francisco, California. The rancho included the land from the bay at Point San Quentin, (later called ) between Mission Creek to the north and Islais Creek and its tributary Precita Creek to the south, including Potrero Hill and land sloping down to the west of it to its boundary with Rancho Rincon de las Salinas y Potrero Viejo between Mission and Precita Creeks.