HIV Resistance Response Database Initiative (RDI) is a not-for-profit organisation established in 2002 with the following mission: To improve the clinical management of HIV infection by developing a large clinical database and bioinformatic techniques that predict accurately any individual's response to any combination of HIV drugs. The RDI has the following specific goals: The RDI consists of a small executive group based in the UK, an international advisory group of leading HIV/AIDS scientists and clinicians, and an extensive global network of collaborators and data contributors.