RhoGEF domain
RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including RhoA, Rac1 and Cdc42. The largest class of RhoGEFs is composed of proteins containing the "Dbl-homology" (DH) domain, which almost always is found together with a pleckstrin-homology (PH) domain to form a combined DH/PH domain structure.
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RhoGEF domain
RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including RhoA, Rac1 and Cdc42. The largest class of RhoGEFs is composed of proteins containing the "Dbl-homology" (DH) domain, which almost always is found together with a pleckstrin-homology (PH) domain to form a combined DH/PH domain structure.
has abstract
RhoGEF domain describes two di ...... ity with DBL-homology domains.
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Symbol
Wikipage page ID
14,683,045
page length (characters) of wiki page
Wikipage revision ID
993,504,343
Link from a Wikipage to another Wikipage
caption
Structure of the RhoGEF domain ...... e of a DOCK/CZH domain RhoGEF.
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Structure of the RhoGEF domain ...... mple of a DH/PH domain RhoGEF.
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CDD
cd00160
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cd11684
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InterPro
IPR000219, IPR035899
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IPR026791, IPR010703
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name
DH/PH RhoGEF domain
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Dedicator of cytokinesis RhoGEF domain
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OPM protein
PDB
E:1044-1233 A:198-372 D:1241 ...... 04-389 B:204-389 A:204-389
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Pfam
PF00621
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PF06920
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SMART
RhoGEF
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symbol
RhoGEF
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wikiPageUsesTemplate
hypernym
comment
RhoGEF domain describes two di ...... mbined DH/PH domain structure.
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label
RhoGEF domain
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