Samuel C. Watson (1832 – March 13, 1892) was a druggist, doctor, and civic leader in Detroit, Michigan and Chatham, Ontario. In the late 1850s and early 1860s, Watson was a part of the Detroit-Chatham Underground Railroad and closely connected with William Whipper and George DeBaptiste. During the American Civil War (1861-1865), Watson settled in Detroit, where he would eventually become a city councilman. He was politically independent, and found himself on opposite sides of debates with DeBaptiste and other Michigan blacks, and he switched from the Republican to the Democratic party in the mid-1880s.