Samuel Houston Mayes (May 11, 1845 – December 12, 1927) of Scots/English-Cherokee descent, was elected as Principal Chief of the Cherokee Nation in Indian Territory (present-day Oklahoma), serving from 1895 to 1899. His maternal grandfather belonged to the Deer clan, and his father was allied with members of the Cherokee Treaty Party in the 1830s, such as the Adair men, Elias Boudinot, and Major Ridge. In the late nineteenth century, his older brother Joel B. Mayes was elected to two terms as Chief of the Cherokee.