The San Marco Altarpiece (also known as Madonna and Saints) is a painting by the Italian early Renaissance painter Fra Angelico, housed in the San Marco Museum of Florence, Italy. It was commissioned by Cosimo de' Medici the Elder, and was completed sometime between 1438 and 1443. The San Marco Altarpiece is known as one of the best early Renaissance paintings for its employment of metaphor and perspective, trompe-l'œil, and the intertwining of Dominican religious themes and symbols with contemporary, political messages.