Sandra J. F. Degen (born c. 1955) is an American biochemist, molecular geneticist and Professor Emerita at the University of Cincinnati Children's Hospital Medical Center in the Department of Pediatrics. Degen was a professor at the University of Cincinnati for over thirty years, where she led a research program focused on probing the biology underlying blood coagulation, growth factors, and growth control. Her lab discovered a novel growth factor called hepatocyte growth factor-like protein. Degen is a member of several national societies and is an elected Fellow of the American Association for the Advancement of Science (AAAS).