Sir William Clayton, 4th Baronet (16 April 1762 – 26 January 1834) of Harleyford Manor, near Great Marlow, Buckinghamshire was an English politician. Clayton was the oldest surviving son of William Clayton (c. 1718 – 1783), who was the grand-nephew of Sir Robert Clayton, a wealthy banker and former Lord Mayor of London. He was educated at Queen's College, Oxford. In 1783, he was elected unopposed was a Member of Parliament (MP) for the rotten borough of Great Marlow, succeeding his father. He held the seat until he stood down at the general election in 1790.