The South Middleborough Historic District encompasses the historic village center of South Middleborough, Massachusetts. The village is located about 6.5 miles (10.5 km) south of the town center, at the junction of Wareham and Locust Streets. Wareham Street (designated Massachusetts Route 28), was for many years the primary route to Cape Cod, until the construction in 1966 of Massachusetts Route 24, a divided highway that bypasses the village. Partly because of the highway, the village center has not been significantly altered since that time.