Ste. Genevieve Historic District is a historic district encompassing much of the built environment of Ste. Genevieve, Missouri. The city was in the late 18th century the capital of Spanish Louisiana, and, at its original location a few miles south, capital of French Louisiana as well. A large area of the city, including fields along the Mississippi River, is a National Historic Landmark District designated in 1960, for its historically French architecture and land-use patterns, while a smaller area, encompassing the parts of the city historically important between about 1790 and 1950, was named separately to the National Register of Historic Places in 2002.