Tebanicline
Tebanicline (ebanicline, ABT-594) is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analog of the potent poison dart frog-derived compound epibatidine, which is about 200 times stronger than morphine as an analgesic, but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.
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Tebanicline
Tebanicline (ebanicline, ABT-594) is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott. It was developed as a less toxic analog of the potent poison dart frog-derived compound epibatidine, which is about 200 times stronger than morphine as an analgesic, but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.
has abstract
Tebanicline (ebanicline, ABT-5 ...... ers resulted in CID:140075813.
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CAS number
198283-73-7
ChEMBL
FDA UNII code
9KX8NKV538
PubChem
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Wikipage page ID
17,712,648
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Wikipage revision ID
1,024,454,695
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ATC prefix
none
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CAS number
ChEMBL
ChemSpiderID
IUPAC name
IUPHAR ligand
PubChem
SMILES
C1CN[C@H]1COC2=CN=CCl
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StdInChIKey
MKTAGSRKQIGEBH-SSDOTTSWSA-N
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Verifiedfields
changed
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verifiedrevid
448,113,374
Watchedfields
changed
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wikiPageUsesTemplate
hypernym
comment
Tebanicline (ebanicline, ABT-5 ...... he α3β4 and the α4β2 subtypes.
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label
Tebanicline
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