U.S. Route 385 (US 385) is a part of the United States Numbered Highway System that travels from Big Bend National Park in Texas to US 85 in Deadwood, South Dakota. Within the state of Nebraska, the highway is known as the Gold Rush Byway, one of nine scenic byways across the state. The highway follows along the old Sidney-Black Hills trail which played a crucial role during the Black Hills Gold Rush in the late 1870s. It served as the primary route to transport gold and mining gear between Sidney, Nebraska and the Black Hills to the north. Today, the highway enters Nebraska in the southeastern portion of the Nebraska Panhandle on the state line with Colorado northeast of Julesburg and continues in a northerly direction to the South Dakota state line north of Chadron.