The second USS Perkins (DD–377) was a Mahan-class destroyer in the United States Navy before and during World War II and named in honour of Commodore George Hamilton Perkins an officer in the United States Navy during the American Civil War. Perkins was laid down on 15 November 1934 at the Puget Sound Navy Yard, Bremerton, Washington. She was launched 31 December 1935, sponsored by Mrs Larz Anderson, commissioned 18 September 1936, with Lieutenant Commander Samuel P. Jenkins in command.