USS S-39 (SS-144) was a United States Navy S-class submarine that saw combat in the Pacific Theater during World War II. She was accidentally run aground on her fifth wartime patrol and was subsequently abandoned. Her keel was laid on 14 January 1919 by the Bethlehem Shipbuilding Corporation, San Francisco, California. She was launched on 2 July 1919 sponsored by Miss Clara M. Huber, and commissioned on 14 September 1923 with Lieutenant John A. Scott (Class of 1918) in command.