VP-21 was a Patrol Squadron of the U.S. Navy. The squadron was established as Established as Bombing Squadron 111 (VB-111) on 30 July 1943, redesignated Patrol Bombing Squadron 111 (VPB-111) on 1 October 1944, redesignated Patrol Squadron 111 (VP-111) on 15 May 1946, redesignated Heavy Patrol Squadron (Landplane) 11 (VP-HL-11) on 15 November 1946, redesignated Patrol Squadron 21 (VP-21) on 1 September 1948 and disestablished on 21 November 1969. It was the fifth squadron to be designated VP-21, the first VP-21 was redesignated VP-45 on 1 July 1939, the second VP-21 was redesignated VP-1 on 30 July 1940, the third VP-21 was disestablished on 18 April 1942 and the fourth VP-21 was redesignated VPB-21 on 1 October 1944.