Van Alstyne Homestead is a historic home located at Canajoharie in Montgomery County, New York. It is a long, low rectangular house with a steeply pitched gambrel roof in the Dutch Colonial style. The original fieldstone house was built before 1730 and has three rooms (loft, living area, kitchen cellar) with a garret under the roof. A 2+1⁄2-story frame addition runs across the rear. It was added to the National Register of Historic Places in 1983. It is located in the Canajoharie Historic District.