The Van Buren Historic District encompasses eight blocks of historic buildings along Main Street in Van Buren, Arkansas. Many of the structures are pre-1920 Victorian and Italianate buildings closely related to the history of commerce in the city. Positioned between the city's train depot and the Arkansas River, the businesses constituting the Van Buren Historic District have played a vital role in the history and economy of the city and region. The district was placed on the National Register of Historic Places as a National Historic District on April 30, 1976.