Vatalanib
Vatalanib (INN, codenamed PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis. It is being studied as a possible treatment for several types of cancer, particularly cancer that is at an advanced stage or has not responded to chemotherapy. Vatalanib is orally active, that is, it is effective when taken by mouth. Vatalanib is being developed by Bayer Schering and Novartis. It inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2.
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Vatalanib
Vatalanib (INN, codenamed PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis. It is being studied as a possible treatment for several types of cancer, particularly cancer that is at an advanced stage or has not responded to chemotherapy. Vatalanib is orally active, that is, it is effective when taken by mouth. Vatalanib is being developed by Bayer Schering and Novartis. It inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2.
has abstract
Vatalanib (INN, codenamed PTK7 ...... is most selective for VEGFR-2.
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CAS number
212141-54-3
ChEBI
ChEMBL
DrugBank
FDA UNII code
5DX9U76296
PubChem
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Wikipage page ID
20,341,296
page length (characters) of wiki page
Wikipage revision ID
1,015,773,751
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ATC prefix
none
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bioavailability
High
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CAS number
ChEBI
ChEMBL
ChemSpiderID
DrugBank
DB04879
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elimination half-life
excretion
Fecal and renal
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IUPAC name
N--4-phthalazin- 1-amine
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IUPHAR ligand
legal status
Investigational
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metabolism
Extensive hepatic metabolism
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pregnancy category
None assigned
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PubChem
routes of administration
Oral
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SMILES
Clc1cccNc3nncCc4ccncc4
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wikiPageUsesTemplate
hypernym
comment
Vatalanib (INN, codenamed PTK7 ...... is most selective for VEGFR-2.
@en
label
Vatalanib
@en