Virginia Man-Yee Lee (born 1945) is a Chinese-born American neuropathologist who specializes in the research of Alzheimer's disease. She is the John H. Ware 3rd Professor in Alzheimer's Research in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania, and Director of the Center for Neurodegenerative Disease Research and Co-director of the Marian S. Ware Alzheimer Drug Discovery Program. She was awarded the 2020 Breakthrough Prize in Life Sciences.