Sir William Humfreys, 1st Baronet (also spelled Humphreys; died 26 October 1735), was a British ironmonger and politician who sat in the House of Commons from 1715 to 1722. He was Lord Mayor of London for 1714–15 and a Director of the Bank of England between 1719 and 1730. He was Member of Parliament in the Parliament of Great Britain for Marlborough from 1715 to 1722. and a Director of the Bank of England in 1719–21, 1722–25, 1726–27 and 1728–30. He was President of Bridewell and Bethlehem Hospitals, Lord of the Manors of Barking and Dagenham.