William Wrightson (29 December 1676 – 1760), of Newcastle-upon-Tyne, was a British landowner, official and Tory politician who sat in the House of Commons between 1710 and 1724. Wrightson was the second son of Robert Wrightson of Cusworth, Yorkshire and his third wife Sarah Beaument, daughter of Sir Thomas Beaumont of Whitley Beaumont, Yorkshire. His early life is obscure but in the early 1700s, he was appointed to Clerk at the Pipe Office, a minor government place worth only £10 a year. His prospects improved when he married Isabel Matthews widow of Thomas Matthews of Newcastle and daughter of Francis Beaumont, merchant, of Newcastle on 2 February 1699. She was the heiress of a significant estate in Newcastle.