The Yarbrough Hotel is a historic building in Huntsville, Alabama. The four-story structure was built of brick and reinforced concrete in 1922–25. The top three floors contain 75 rooms, while the ground floor features the hotel lobby and storefronts; as it did not have a ballroom or party rooms, it catered to businessmen. It faced competition from the Twickenham Hotel one block away, and the Russel Erskine Hotel (opened 1930). Yarbrough operated as a residential hotel until the late 1950s, and was renovated in the 1980s.