14-Methoxymetopon
14-Methoxymetopon is an opiate analogue developed by a team led by Professor Helmut Schmidhammer at the University of Insbruck in the mid 1990s. It is a derivative of metopon in which a methoxy group has been inserted at the 14-position. It is a highly potent analgesic drug that is around 500x stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine. It binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs. This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent μ-opioid full agonist in regard to some effects such as analgesia, a ceiling effect is seen on other effects such as c
primaryTopic
14-Methoxymetopon
14-Methoxymetopon is an opiate analogue developed by a team led by Professor Helmut Schmidhammer at the University of Insbruck in the mid 1990s. It is a derivative of metopon in which a methoxy group has been inserted at the 14-position. It is a highly potent analgesic drug that is around 500x stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine. It binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs. This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent μ-opioid full agonist in regard to some effects such as analgesia, a ceiling effect is seen on other effects such as c
has abstract
14-Methoxymetopon is an opiate ...... ion with the κ-opioid receptor
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CAS number
131575-03-6
IUPAC name
3-Hydroxy-14-methoxy-5,17-dimethyl-7,8-dihydro-4,5α-epoxy-morphinan-6-one
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PubChem
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Wikipage page ID
17,016,406
Wikipage revision ID
713,189,646
Caption
chemical structure
ChEMBL
ChemSpiderID
molecular weight
smiles
C[C@]12CCC[C@@]3OC
StdInChIKey
DENICFHULARDRG-WEZQJLTASA-N
synonyms
Verifiedfields
verifiedrevid
477,209,012
Watchedfields
hypernym
comment
14-Methoxymetopon is an opiate ...... een on other effects such as c
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label
14-Methoxymetopon
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