The 1900 Detroit Titans football team was an American football team that represented the University of Detroit in the 1900 college football season. In its first season under head coach John C. Mackey, the team compiled a 3–3 record and outscored its opponents by a combined total of 71 to 23. Five of the team's opponents were high schools. The only intercollegiate game was an 11-0 victory over Loyola University Chicago.