The 1906 Carlisle vs. Vanderbilt football game, played November 22, 1906 was a college football game between the Carlisle Indians and Vanderbilt Commodores. Vanderbilt defeated the northern school by a single, 17-yard Bob Blake field goal, Vanderbilt coach Dan McGugin described the win as "the crowning feat of the Southern Intercollegiate Athletic Association season." The 1906 Vanderbilt team had one of the greatest seasons in school history, once rated by Innis Brown as the best the South ever had.