The 1965 Ohio Bobcats football team was an American football team that represented Ohio University in the Mid-American Conference (MAC) during the 1965 college football season. In their eighth season under head coach Bill Hess, the Bobcats compiled a 0–10 record (0–6 against MAC opponents), finished in seventh place in the MAC, and were outscored by all opponents by a combined total of 210 to 77. The team's statistical leaders included Sam Bogan with 308 rushing yards, Sam Fornsaglio with 305 passing yards, and Glenn Hill with 201 receiving yards.