The 1980–81 Yugoslav Cup was the 33rd season of the top football knockout competition in SFR Yugoslavia, the Yugoslav Cup (Serbo-Croatian: 'Kup Jugoslavije'), also known as the "Marshal Tito Cup" (Kup Maršala Tita), since its establishment in 1946. The reigning 1979–80 cup holders Dinamo Zagreb failed to retain the trophy as they were knocked out in the second round by Radnički Niš. Velež from Mostar and Željezničar from Sarajevo reached the tournament final, in what would become the only cup final contested by two clubs from Bosnia and Herzegovina in the history of the competition.