The 25th Virginia Volunteer Infantry Regiment was an infantry regiment raised in Virginia for service in the Confederate States Army during the American Civil War. It fought mostly with the Army of the Northwest and Army of Northern Virginia. Its brave soldiers saw action from the first battle (Philippi) until the last (Appomattox). The field officers were Colonels John C. Higginbotham, George A. Porterfield, and George H. Smith; Lieutenant Colonels Patrick B. Duffy, Jonathan McGee Heck, Robert D. Lilley, and John A. Robinson; and Majors Wilson Harper, Albert G. Reger, and William T. Thompson.