The 44th Indiana Infantry, an American Civil War regiment, was organized at Fort Wayne, Indiana, on October 24, 1861, with Hugh B. Reed, a Fort Wayne druggist, as colonel, and officially mustered in on November 22, 1861. It was composed mostly of volunteers from what was then Indiana's Tenth Congressional District in the northeastern part of the state. In December, the regiment left for Henderson, Kentucky. It camped at Calhoun, Kentucky, until February 1862, when it moved to Fort Henry, Tennessee, then to Fort Donelson, Tennessee, where it participated in the siege of the fort, taking heavy casualties there.