AD-1211
AD-1211 is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-prenyl-piperazine derivative, which is structurally unrelated to most other opioid drugs. The (S) enantiomers in this series are more active as opioid agonists, but the less active (R) enantiomer of this compound, AD-1211, is a mixed agonist–antagonist at opioid receptors with a similar pharmacological profile to pentazocine, and has atypical opioid effects with little development of tolerance or dependence seen after extended administration in animal studies.
primaryTopic
AD-1211
AD-1211 is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-prenyl-piperazine derivative, which is structurally unrelated to most other opioid drugs. The (S) enantiomers in this series are more active as opioid agonists, but the less active (R) enantiomer of this compound, AD-1211, is a mixed agonist–antagonist at opioid receptors with a similar pharmacological profile to pentazocine, and has atypical opioid effects with little development of tolerance or dependence seen after extended administration in animal studies.
has abstract
AD-1211 is an opioid analgesic ...... inistration in animal studies.
@en
ATC prefix
CAS number
83374-58-7
CAS supplemental
61311-01-1 (R) enantiomer
IUPAC name
1-(3-methyl-2-butenyl)-4-[(1R)-1-phenyl-2-(3-hydroxyphenyl)ethyl]piperazine
@en
PubChem
thumbnail
Wikipage page ID
31,291,508
Wikipage revision ID
721,235,595
ChemSpiderID
26,286,944
molecular weight
3.50496e+2
smiles
c1ccccc1CCNCCN2C\C=C/C
StdInChIKey
WLHCNEPBQJOHKW-HSZRJFAPSA-N
synonyms
verifiedrevid
462,651,127
hypernym
comment
AD-1211 is an opioid analgesic ...... inistration in animal studies.
@en
label
AD-1211
@en