Adrenorphin
Adrenorphin, also sometimes referred to as metorphamide, is an endogenous, C-terminally amidated, opioid octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2) that is produced from proteolytic cleavage of proenkephalin A and is widely distributed throughout the mammalian brain. It was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. Adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors. It possesses analgesic and respiratory depressive properties.
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Adrenorphin
Adrenorphin, also sometimes referred to as metorphamide, is an endogenous, C-terminally amidated, opioid octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2) that is produced from proteolytic cleavage of proenkephalin A and is widely distributed throughout the mammalian brain. It was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. Adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors. It possesses analgesic and respiratory depressive properties.
has abstract
Adrenorphin, also sometimes re ...... iratory depressive properties.
@en
アドレノルフィン(Adrenorphin)は、内生の、C末端 ...... �い、強いオピオイド活性を示す。呼吸抑制や鎮痛の効果を持つ。
@ja
IUPAC name
(L)-tyrosylglycylglycyl-(L)-ph ...... nyl-(L)-arginyl-(L)-valinamide
@en
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Wikipage page ID
28,584,333
Wikipage revision ID
721,304,458
imagesize
Verifiedfields
verifiedrevid
477,243,096
Watchedfields
hypernym
comment
Adrenorphin, also sometimes re ...... iratory depressive properties.
@en
アドレノルフィン(Adrenorphin)は、内生の、C末端 ...... ない、強いオピオイド活性を示す。呼吸抑制や鎮痛の効果を持つ。
@ja
label
Adrenorphin
@en
アドレノルフィン
@ja