Alexander of Lycopolis was the writer of a short treatise, in twenty-six chapters, against the Manicheans (J. P. Migne, Patrologia Graeca, XVIII, 409-448). He says in the second chapter of this work that he derived his knowledge of Manes' teaching apo ton gnorimon (from the man's friend). The work is a specimen of Greek analytical procedure in the service of Christian theology, "a calm but vigorous protest of the trained scientific intellect against the vague dogmatism of the Oriental theosophies".