Alfentanil
Alfentanil (R-39209, trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around 1/4 to 1/10 the potency of fentanyl and around 1/3 of the duration of action, but with an onset of effects 4x faster than fentanyl. Alfentanil has a pKa of approximately 6.5, which leads to a very high proportion of the drug being uncharged at physiologic pH. This unique characteristic is responsible for its rapid onset. It is an agonist at mu opioid receptors.
primaryTopic
Alfentanil
Alfentanil (R-39209, trade name Alfenta, Rapifen in Australia) is a potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery. It is an analogue of fentanyl with around 1/4 to 1/10 the potency of fentanyl and around 1/3 of the duration of action, but with an onset of effects 4x faster than fentanyl. Alfentanil has a pKa of approximately 6.5, which leads to a very high proportion of the drug being uncharged at physiologic pH. This unique characteristic is responsible for its rapid onset. It is an agonist at mu opioid receptors.
has abstract
Alfentanil (Handelsnamen Rapif ...... gt dem Betäubungsmittelgesetz.
@de
Alfentanil (R-39209, trade nam ...... erivatives continue to appear.
@en
Alfentanil is een synthetisch ...... Staten is de merknaam Alfenta.
@nl
Alfentanil è un potente oppioi ...... lare precisamente il dosaggio.
@it
Alfentanil é um opióide sintét ...... al. legal muito bom para saúde
@pt
Alfentanyl – organiczny związe ...... epresyjnie na mięsień sercowy.
@pl
El alfentanilo es un fármaco a ...... Janssen Pharmaceutica en 1976.
@es
L'alfentanil (Rapifen, R39209) ...... pour la première fois en 1976.
@fr
ATC prefix
ATC suffix
Bioavailability
CAS number
71195-58-9
DrugBank
FDA UNII code
1N74HM2BS7
IUPAC name
N-{1-[2-(4-ethyl-5-oxo-4,5-dih ...... idin-4-yl}-N-phenylpropanamide
@en
PubChem
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Link from a Wikipage to an external page
Wikipage page ID
Wikipage revision ID
734,363,197
ChemSpiderID
duration of action
elimination half-life
IUPHAR ligand
legal CA
legal DE
legal UK
legal US
MedlinePlus
melting point
metabolism
molecular weight
4.16517e+2
protein bound
routes of administration
smiles
O=C1NCCN3CCCCOC
StdInChIKey
IDBPHNDTYPBSNI-UHFFFAOYSA-N
tradename
verifiedrevid
477,317,188
subject
comment
Alfentanil (Handelsnamen Rapif ...... gt dem Betäubungsmittelgesetz.
@de
Alfentanil (R-39209, trade nam ...... gonist at mu opioid receptors.
@en
Alfentanil is een synthetisch ...... a de operatie is daarom nodig.
@nl
Alfentanil è un potente oppioi ...... di controllare precisamente i
@it
Alfentanil é um opióide sintét ...... al. legal muito bom para saúde
@pt
Alfentanyl – organiczny związe ...... epresyjnie na mięsień sercowy.
@pl
El alfentanilo es un fármaco a ...... o a su más rápida eliminación.
@es
L'alfentanil (Rapifen, R39209) ...... pour la première fois en 1976.
@fr
label
Alfentanil
@de
Alfentanil
@en
Alfentanil
@fr
Alfentanil
@it
Alfentanil
@nl
Alfentanil
@pt
Alfentanilo
@es
Alfentanyl
@pl