Anfinsen's dogma

Anfinsen's dogma (also known as the thermodynamic hypothesis) is a postulate in molecular biology that, at least for small globular proteins, the native structure is determined only by the protein's amino acid sequence. The dogma was championed by the Nobel Prize Laureate Christian B. Anfinsen from his research on the folding of ribonuclease A. The postulate amounts to saying that, at the environmental conditions (temperature, solvent concentration and composition, etc.) at which folding occurs, the native structure is a unique, stable and kinetically accessible minimum of the free energy.The three conditions:

Anfinsen's dogma

Anfinsen's dogma (also known as the thermodynamic hypothesis) is a postulate in molecular biology that, at least for small globular proteins, the native structure is determined only by the protein's amino acid sequence. The dogma was championed by the Nobel Prize Laureate Christian B. Anfinsen from his research on the folding of ribonuclease A. The postulate amounts to saying that, at the environmental conditions (temperature, solvent concentration and composition, etc.) at which folding occurs, the native structure is a unique, stable and kinetically accessible minimum of the free energy.The three conditions: