Anna Komnene Doukaina (died 4 January 1286), known in French as Agnes, was Princess-consort of the Principality of Achaea in 1258–1278. Anna was a daughter of the ruler of Epirus, Michael II Komnenos Doukas, and his wife, Theodora. In 1258, she was married to the Prince of Achaea, William II of Villehardouin, at Patras, while her sister Helena was married to Manfred of Hohenstaufen, King of Sicily. These marriages were part of a web of alliances directed against the Empire of Nicaea, whose expansion threatened both the interests of the Epirote ruler, who claimed the Byzantine imperial heritage for himself, and the very existence of the Latin states of Greece. The diplomatic and military manoeuvring that followed led to the eventual defeat of the Epirote–Latin alliance in the Battle of Pela