Apama II, sometimes known as Apame II (Ancient Greek: Ἀπάμα, about c. 292 BC-sometime after 249 BC) was a Syrian Greek Princess of the Seleucid Empire and through marriage was a Queen of Cyrenaica. Apama II was a daughter of the second Seleucid King Antiochus I Soter, who was of Greek Macedonian and Persian descent, and Queen Stratonice of Syria, who was Greek Macedonian descent. Her siblings included Stratonice of Macedon and the Seleucid King Antiochus II Theos. Her paternal grandparents were the first Seleucid King Seleucus I Nicator and his wife Queen Apama I, and her maternal grandparents were Antigonid King Demetrius I of Macedon and his wife Queen Phila. Apama was the namesake of her paternal grandmother and paternal aunt. Apama was born and raised in the Seleucid Empire.