Bardoxolone methyl
Bardoxolone methyl (also known as “RTA 402”, “CDDO-methyl ester”, and CDDO-Me) is an experimental and orally-available semi-synthetic triterpenoid, based on the scaffold of the natural product oleanolic acid. Pre-clinical studies indicate that the compound acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. A phase 3 clinical trial evaluating bardoxolone methyl for the treatment of chronic kidney disease (CKD) was terminated in October 2012 after patients treated with the drug were found to have experienced a higher rate of heart-related adverse events, including heart failure, hospitalizations, and deaths.
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Bardoxolone methyl
Bardoxolone methyl (also known as “RTA 402”, “CDDO-methyl ester”, and CDDO-Me) is an experimental and orally-available semi-synthetic triterpenoid, based on the scaffold of the natural product oleanolic acid. Pre-clinical studies indicate that the compound acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. A phase 3 clinical trial evaluating bardoxolone methyl for the treatment of chronic kidney disease (CKD) was terminated in October 2012 after patients treated with the drug were found to have experienced a higher rate of heart-related adverse events, including heart failure, hospitalizations, and deaths.
has abstract
Bardoxolone methyl (also known ...... hospitalizations, and deaths.
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ATC prefix
CAS number
218600-53-4
IUPAC name
Methyl 2-cyano-3,12-dioxooleana-1,9(11)dien-28-oate
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PubChem
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Wikipage page ID
23,945,739
Wikipage revision ID
728,994,184
ChEMBL
ChemSpiderID
IUPHAR ligand
legal status
Investigational
molecular weight
routes of administration
smiles
O=C4C=C/[C@@]5C
StdInChIKey
WPTTVJLTNAWYAO-KPOXMGGZSA-N
Verifiedfields
verifiedrevid
461,217,017
Watchedfields
subject
hypernym
comment
Bardoxolone methyl (also known ...... hospitalizations, and deaths.
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label
Bardoxolone methyl
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