Benorterone

Benorterone (INN, USAN) (developmental code names SKF-7690, FC-612), also known as 17α-methyl-B-nortestosterone, is a steroidal, pure antiandrogen that was never marketed. Unlike other steroidal antiandrogens such as cyproterone acetate (CPA), it is not also a progestogen, instead acting as a selective androgen receptor antagonist similarly to non-steroidal antiandrogens such as bicalutamide. However, although it is described as not being a progestogen, benorterone was found to produce "a highly variable decrease in plasma testosterone levels" (the reasons for this are unclear, as other pure antiandrogens such as cyproterone (not CPA) and bicalutamide do not do this and instead produce consistent increases in testosterone levels).

Benorterone

Benorterone (INN, USAN) (developmental code names SKF-7690, FC-612), also known as 17α-methyl-B-nortestosterone, is a steroidal, pure antiandrogen that was never marketed. Unlike other steroidal antiandrogens such as cyproterone acetate (CPA), it is not also a progestogen, instead acting as a selective androgen receptor antagonist similarly to non-steroidal antiandrogens such as bicalutamide. However, although it is described as not being a progestogen, benorterone was found to produce "a highly variable decrease in plasma testosterone levels" (the reasons for this are unclear, as other pure antiandrogens such as cyproterone (not CPA) and bicalutamide do not do this and instead produce consistent increases in testosterone levels).