Bruinsburg is a ghost town in Claiborne County, Mississippi, United States. It was located on the south bank of the Bayou Pierre, 3.0 mi (4.8 km) east of the Mississippi River. The town's port, Bruinsburg Landing, was located directly on the Mississippi River, just south of the mouth of the Bayou Pierre. Once an important commercial and military location, nothing remains today of the town or its port.