The Cambridge Street School is a historic former school building at 510 Cambridge Street in Worcester, Massachusetts. Built in 1869 and twice enlarged substantially, it is notable for including the only surviving unaltered Second Empire school building in the city. The building served Worcester's public school students until 1976; the city sold the building in 1978. It now serves as a transitional housing facility for homeless families. The building was listed on the National Register of Historic Places in 1980.