The Chatham Southern Railway Depot is a historic train station at 340 Whitehead Street in Chatham, Virginia. It is a long rectangular single story masonry structure, from which a polygonal tower rises on 1-1/2 stories on the track side. It has a hipped roof with flared eaves supported by large wooden brackets. Built in 1918-19 by the Southern Railway, it was a major hub of the city's economic activity until passenger service was discontinued in 1965, and freight service in 1975. It has been owned by the Pittsylvania County Historical Society since 2001, which plans to restore the building and use it as a veterans' museum.