Cilastatin
Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta-lactamase that usually confer antibiotic resistance to certain bacteria; more precisely the carbapenem family of antibiotics. This property is due to the physico-chemical similarities between membrane dipeptidase (MDP), the compound it is usually set to
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Cilastatin
Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta-lactamase that usually confer antibiotic resistance to certain bacteria; more precisely the carbapenem family of antibiotics. This property is due to the physico-chemical similarities between membrane dipeptidase (MDP), the compound it is usually set to
has abstract
Cilastatin is a chemical compo ...... tor, not an antibiotic per se.
@en
Cilastatin ist eine chemische ...... Sharp & Dohme (MSD) im Handel.
@de
Cilastatine is een organisch z ...... meeste andere Europese landen.
@nl
Cylastyna – organiczny związek ...... a łącznie z tym antybiotykiem.
@pl
La cilastatina es un compuesto ...... o tiene actividad antibiótica.
@es
La cilastatine est un inhibite ...... te mise à jour en avril 2013).
@fr
ATC prefix
ATC suffix
ATC supplemental
(combination withimipenem)
CAS number
82009-34-5
DrugBank
FDA UNII code
141A6AMN38
IUPAC name
(Z)-7-[(2R)-2-Amino-3-hydroxy- ...... rbonyl]amino}hept-2-enoic acid
@en
PubChem
thumbnail
Wikipage page ID
Wikipage revision ID
725,313,063
ChemSpiderID
IUPHAR ligand
MedlinePlus
molecular weight
3.58454e+2
routes of administration
smiles
StdInChIKey
DHSUYTOATWAVLW-WFVMDLQDSA-N
verifiedrevid
460,036,539
Watchedfields
hypernym
comment
Cilastatin is a chemical compo ...... compound it is usually set to
@en
Cilastatin ist eine chemische ...... ck patentiert und ist in Kombi
@de
Cilastatine is een organisch z ...... gt zo de werking van imipenem.
@nl
Cylastyna – organiczny związek ...... a łącznie z tym antybiotykiem.
@pl
La cilastatina es un compuesto ...... o tiene actividad antibiótica.
@es
La cilastatine est un inhibite ...... radé par la déshydropeptidase.
@fr
label
Cilastatin
@de
Cilastatin
@en
Cilastatina
@es
Cilastatine
@fr
Cilastatine
@nl
Cylastatyna
@pl