Clotworthy Skeffington, 1st Earl of Massereene PC (I) (1715 – 14 September 1757) was an Anglo-Irish peer. Massereene was the son of Clotworthy Skeffington, 4th Viscount Massereene and Lady Catherine Chichester, daughter of Arthur Chichester, 3rd Earl of Donegall. He succeeded to his father's title in 1738 and assumed his seat in the Irish House of Lords. He was made a Member of the Privy Council of Ireland in 1746, and on 28 July 1756 he was created Earl of Massereene in the Peerage of Ireland. He died suddenly just over a year later.