Crescent Creek is a 30-mile (48 km) tributary of the Little Deschutes River in Klamath County in the U.S. state of Oregon. Beginning at Crescent Lake on the eastern flank of the Cascade Range, the river flows generally east through parts of Deschutes National Forest to meet the Little Deschutes between Crescent and La Pine. The creek supports native rainbow trout, non-native brown trout and brook trout, and other species. The healthy and remote riparian zone along the upper creek supports a diversity of grasses, sedges, willows, and many species of birds, mammals, and amphibians.