The Daniel and Mary Lee House is a historic house on the north side of Pepperidge Road, east of Jobs Pond Road in Portland, Connecticut. It is a two story wood frame structure, three bays wide, with a central chimney. A single story shed-roof ell, part of the house's original construction, extends to the rear. It has a side-hall plan inside, an atypical layout for traditional 18th-century houses. The house was built in 1770, and is the only known house of its type to survive in the area. Its interior is well-preserved. The house was listed on the National Register of Historic Places in 1991.